The Hires Root Beer Story...

Hires Root Beer was created by Philadelphia pharmacist Charles Elmer Hires. The official story is that Hires first tasted root beer, a traditional American beverage dating back to the colonial era, while on his honeymoon in 1875. However, historical accounts vary and the actual time and place of the discovery may never be known. By 1876, Hires had developed his own recipe and was marketing 25-cent packets of powder which each yielded five gallons of root beer. At Philadelphia's Centennial Exposition in 1876, he cultivated new customers by giving away free glasses of root beer. Hires marketed it as a solid concentrate of sixteen wild roots and berries. It claimed to purify the blood and make rosy cheeks. In 1884, he began producing a liquid extract and a syrup for use in soda fountains, and was soon shipping root beer in kegs and producing a special fountain dispenser called the "Hires Automatic Munimaker." In 1890, the Charles E. Hires Company incorporated and began supplying Hires root beer in small bottles, claiming over a million bottles sold by 1891.

But Hires's choice of name for his product caused a problem: the word "beer" drew the wrath of the temperance movement. He had his root beer tested by a laboratory, and trumpeted their conclusion that a glass of his root beer contained less alcohol than a loaf of bread. Hires Root Beer was promoted as "The Temperance Drink" and "the Greatest Health-Giving Beverage in the World." Hires advertised aggressively, believing "doing business without advertising is like winking at a girl in the dark. You know what you are doing, but nobody ELSE does."

Hires Root Beer mug, 1930s or earlier

One of the major ingredients of root beer was sassafras oil, a plant root extract used in beverages for its flavor and presumed medicinal properties. The medicinal properties of root beer are emphasized in the advertising slogan, "Join Health and Cheer; Drink Hires Root Beer." The U.S. Food and Drug Administration banned sassafras oil in 1960 because it contains the carcinogen and liver-damaging chemical safrol. However, a process was later discovered by which the harmful chemical could be removed from sassafras oil while preserving the flavor.

Prior to the move to "natural and artificial flavors", Hires ingredients included carbonated water, sugar, dextrose, caramel, plant extracts of birch, sassafras, licorice, vanilla, spikenard, sarsaparilla, hops, wintergreen, pipsissewa, ginger and flavor.

Hires Root Beer kits, available in the United States and Canada from the early 1900s through the 1980s allowed consumers to mix an extract with water, sugar and yeast to brew their own root beer. However, most consumption was of pre-bottled root beer.

A mid-1960s' advertising campaign featured jingles by jazz singer Blossom Dearie, wherein she sang in a Betty-Boop voice: "Hires Root Beer! Hires Rootin' Tootin' Root Beer! Hires Rootin'-Tootin' Rabble-Rousin', lion-roarin', Roman-candle-lightin' Root Beer!"

How to Make Cheese Seftons, --- The Victorian Way...

Chloral Hydrate In Victorian Times...

Chloral hydrate was first synthesized by the chemist Justus von Liebig in 1832 at the University of Giessen. Through experimentation physiologist Claude Bernard clarified that the chloral hydrate was hypnotic as opposed to an analgesic.  It was the first of a long line of sedatives, most notably the barbiturates, manufactured and marketed by the German pharmaceutical industry. 

Historically, chloral hydrate was utilized primarily as a psychiatric medication. In 1869, German physician and pharmacologist Oscar Liebreich began to promote its use to calm anxiety, especially when it caused insomnia. Chloral hydrate had certain advantages over morphine for this application, as it worked quickly without injection and had a consistent strength. It achieved wide use in both asylums and the homes of those socially refined enough to avoid asylums. Upper- and middle-class women, well-represented in the latter category, were particularly susceptible to chloral hydrate addiction. After the 1904 invention of barbital, the first of the barbiturate family, chloral hydrate began to disappear from use among those with means. It remained common in asylums and hospitals until the Second World War as it was quite cheap. Chloral hydrate had some other important advantages that kept it in use for five decades despite the existence of more advanced barbiturates. It was the safest available sedative until the middle of the twentieth century, and thus was particularly favored for children.  It also left patients much more refreshed after a deep sleep than more recently invented sedatives. Its frequency of use made it an early and regular feature in The Merck Manual.

Chloral hydrate was also a significant object of study in various early pharmacological experiments. In 1875, Claude Bernard tried to determine if chloral hydrate exerted its action through a metabolic conversion to chloroform. This was not only the first attempt to determine whether different drugs were converted to the same metabolite in the body but also the first to measure the concentration of a particular pharmaceutical in the blood. The results were inconclusive.  In 1899 and 1901 Hans Horst Meyer and Ernest Overton respectively made the major discovery that the general anesthetic action of a drug was strongly correlated to its lipid solubility. However, chloral hydrate was quite polar but nonetheless a potent hypnotic. Overton was unable to explain this mystery. Thus, chloral hydrate remained one of the major and persistent exceptions to this breakthrough discovery in pharmacology. This anomaly was eventually resolved in 1948, when Claude Bernard's experiment was repeated. While chloral hydrate was converted to a different metabolite than chloroform, it was found that was converted into the more lipophilic molecule 2,2,2-Trichloroethanol. This metabolite fit much better with the Meyer–Overton correlation than chloral had. Prior to this, it had not been demonstrated that general anesthetics could undergo chemical changes to exert their action in the body.

Finally, chloral hydrate was also the first hypnotic to be used intravenously as a general anesthetic. In 1871, Pierre-Cyprien Oré began experiments on animals, followed by humans. While a state of general anesthesia could be achieved, the technique never caught on because its administration was more complex and less safe than the oral administration of chloral hydrate, and less safe for intravenous use than later general anesthetics were found to be.